| Characteristics | Details |
|---|---|
| Active Ingredients | Sildenafil 100 mg, Duloxetine 30 mg |
| Form | Tablet |
| Indications | Erectile Dysfunction, Premature Ejaculation |
| Route | Oral |
| Duration of Action | 4-6 hours |
| More about Malegra DXT Plus | |
Chemical Structure
The chemical blueprint of Malegra DXT Plus reveals two active compounds: sildenafil and duloxetine. Sildenafil 100 mg, a PDE5 inhibitor, exists as a crystalline structure. It bonds to the phosphodiesterase enzyme with high affinity. Duloxetine 30 mg, an SNRI, features a similar affinity for serotonin and norepinephrine transporters. The molecules intertwine in Malegra DXT Plus, offering a robust pharmaceutical profile. Its precise assembly ensures efficacy in addressing erectile dysfunction and premature ejaculation.
Mechanism of Action
Sildenafil 100 mg targets the smooth muscle of penile tissue. It restricts PDE5 enzyme function, elevating cyclic GMP levels. This biochemical cascade facilitates relaxation and engorgement. Duloxetine 30 mg operates on central nervous system neurotransmitters. It extends the availability of serotonin and norepinephrine. This prolongs the latency to ejaculation, countering premature ejaculation. Together, these agents in Malegra DXT Plus modulate distinct yet complementary pathways, augmenting sexual performance.
Malegra DXT Plus Contraindications
Certain patient conditions contraindicate Malegra DXT Plus usage. Hypersensitivity to sildenafil or duloxetine mandates exclusion. Severe cardiovascular disorders, such as unstable angina, contraindicate sildenafil due to potential cardiac strain. Patients with hepatic insufficiency or severe renal impairment should avoid duloxetine due to impaired metabolism. Malegra DXT Plus should not coincide with nitrate therapy, as it risks precipitous hypotension.
Cautions with Other Medicines
Simultaneous administration with specific drugs warrants caution. Antihypertensives, when combined with sildenafil 100 mg, may amplify hypotensive effects. Serotonin syndrome risk escalates when duloxetine 30 mg aligns with MAO inhibitors. CYP3A4 inhibitors can heighten sildenafil plasma levels, enhancing side effects. Concomitant use of aspirin and NSAIDs with duloxetine may increase bleeding risk. An informed clinical approach is vital.
Malegra DXT Plus Side Effects
Like many pharmaceuticals, Malegra DXT Plus carries potential adverse effects. Common reactions include headache, dizziness, and facial flushing from sildenafil. Duloxetine may induce nausea, dry mouth, or insomnia. Rare but serious effects like sudden vision loss require immediate attention. The occurrence of priapism, an emergency condition, necessitates urgent intervention. Monitoring and reporting symptoms ensure patient safety.
Malegra DXT Plus for Sale Online
Malegra DXT Plus availability extends through various online platforms. It’s pivotal to procure from reputable sources to avoid counterfeit products. Patients should verify online pharmacy credentials. Consultation with healthcare professionals before acquisition ensures appropriate usage. Secure transactions and privacy policies enhance the buying experience. Consideration of patient reviews may guide purchasing decisions.
| Side Effect | Frequency |
|---|---|
| Headache | Common |
| Dizziness | Common |
| Nausea | Occasional |
- Active Ingredients: Sildenafil, Duloxetine
- Therapeutic Area: Sexual Health
- Contraindications: Cardiac Disorders, Hypersensitivity
- Common Side Effects: Headache, Nausea
