/* global FusionApp, fusionAllElements, FusionPageBuilderApp */ var FusionPageBuilder = FusionPageBuilder || {}; ( function () { jQuery( document ).ready( function () { FusionPageBuilder.fusion_submenu = FusionPageBuilder.ElementView.extend( { onRender: function() { var self = this; setTimeout( function() { jQuery( '#fb-preview' )[ 0 ].contentWindow.jQuery( 'body' ).trigger( 'fusion-element-render-fusion_menu', self.model.get( 'cid' ) ); }, 300 ); }, /** * Modify template attributes. * * @since 3.0 * @param {Object} atts - The attributes object. * @return {Object} */ filterTemplateAtts: function ( atts ) { var attributes = {}; this.values = atts.values; // Force opacity submenu transition for vertical menus. this.values.expand_transition = 'row' !== this.values.direction ? 'opacity' : this.values.expand_transition; attributes.attr = this.buildAttr(); attributes.menuMarkup = 'undefined' !== typeof atts.query_data && 'undefined' !== typeof atts.query_data.menu_markup ? atts.query_data.menu_markup : 'No menu markup'; return attributes; }, isDefault: function( param ) { return this.values[ param ] === fusionAllElements.fusion_submenu.defaults[ param ]; }, /** * Builds attributes. * * @since 3.0 * @return {Object} */ buildAttr: function () { var attr = { class: [ 'awb-submenu', 'awb-submenu_' + this.values.direction, 'awb-submenu_icons-' + this.values.icons_position, 'awb-submenu_dc-' + this.values.dropdown_carets ].join( ' ' ), style: '' }, cssVarsOptions, cssVariables, self = this; let expandMethod = this.values.expand_method; if ( 'stacked' === this.values.submenu_mode && 'column' === this.values.direction ) { attr[ 'class' ] += ' awb-submenu_v-stacked'; if ( 'always' === this.values.stacked_expand_method ) { attr[ 'class' ] += ' awb-submenu_em-always'; } expandMethod = this.values.stacked_expand_method; if ( 'always' === this.values.stacked_expand_method ) { expandMethod = 'click'; } if ( 'click' === this.values.stacked_expand_method ) { attr[ 'class' ] += ' awb-submenu_cm_' + this.values.stacked_click_mode; } } else { attr[ 'class' ] += ' awb-submenu_dropdown'; attr[ 'class' ] += ' awb-submenu_expand-' + this.values.expand_direction; attr[ 'class' ] += ' awb-submenu_transition-' + this.values.expand_transition; } attr[ 'class' ] += ' awb-submenu_em-' + expandMethod; attr[ 'data-cid' ] = this.model.get( 'cid' ); attr[ 'class' ] += _.fusionGetStickyClass( this.values.sticky_display ); attr[ 'data-transition-type' ] = this.values.transition_type; if ( '' !== this.values[ 'class' ] ) { attr[ 'class' ] += ' ' + this.values[ 'class' ]; } if ( '' !== this.values.id ) { attr.id = this.values.id; } attr = _.fusionAnimations( this.values, attr ); attr = _.fusionVisibilityAtts( this.values.hide_on_mobile, attr ); this.values.main_justify_content = this.values.main_justify_content.replace( 'left', 'flex-start' ).replace( 'right', 'flex-end' ); this.values.sub_justify_content = this.values.sub_justify_content.replace( 'left', 'flex-start' ).replace( 'right', 'flex-end' ); cssVarsOptions = [ 'line_height', 'transition_time', 'fusion_font_family_typography', 'fusion_font_variant_typography', 'text_transform', 'bg', 'align_items', 'justify_content', 'border_color', 'color', 'active_color', 'active_bg', 'active_border_color', 'submenu_color', 'submenu_bg', 'submenu_sep_color', 'submenu_items_padding_top', 'submenu_items_padding_right', 'submenu_items_padding_bottom', 'submenu_items_padding_left', 'fusion_font_family_submenu_typography', 'fusion_font_variant_submenu_typography', 'submenu_active_bg', 'submenu_active_color', 'submenu_space', 'submenu_text_transform', 'submenu_line_height', 'submenu_letter_spacing', 'submenu_max_width', 'icons_size', 'icons_color', 'icons_hover_color', 'main_justify_content', 'sub_justify_content', 'sticky_min_height', 'stacked_submenu_indent' ]; cssVarsOptions.margin_top = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.margin_bottom = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.items_padding_top = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.items_padding_bottom = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.items_padding_left = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.items_padding_right = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.gap = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.font_size = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.min_height = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.border_top = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.border_bottom = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.border_left = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.border_right = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.active_border_top = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.active_border_bottom = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.active_border_left = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.active_border_right = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.border_radius_top_left = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.border_radius_top_right = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.border_radius_bottom_right = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.border_radius_bottom_left = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.submenu_border_radius_top_left = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.submenu_border_radius_top_right = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.submenu_border_radius_bottom_right = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.submenu_border_radius_bottom_left = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.submenu_space = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.submenu_items_padding_top = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.submenu_items_padding_bottom = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.submenu_items_padding_left = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.submenu_items_padding_right = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.submenu_font_size = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.thumbnail_size_width = { 'callback': _.fusionGetValueWithUnit }; cssVarsOptions.thumbnail_size_height = { 'callback': _.fusionGetValueWithUnit }; attr.style += this.getCssVarsForOptions( cssVarsOptions ); cssVariables = {}; // Add box shadow as a full string. if ( 'yes' === this.values.box_shadow ) { cssVariables.box_shadow = _.fusionGetBoxShadowStyle( this.values ); } jQuery.each( _.fusionGetFontStyle( 'typography', self.values, 'object' ), function( rule, value ) { cssVariables[ 'fusion-' + rule + '-typography' ] = value; } ); jQuery.each( _.fusionGetFontStyle( 'submenu_typography', self.values, 'object' ), function( rule, value ) { cssVariables[ 'fusion-' + rule + '-submenu-typography' ] = value; } ); attr.style += this.getCustomCssVars( cssVariables ); return attr; }, /** * Runs just after render on cancel. * * @since 3.5 * @return null */ beforeGenerateShortcode: function() { var elementType = this.model.get( 'element_type' ), options = fusionAllElements[ elementType ].params, values = jQuery.extend( true, {}, fusionAllElements[ elementType ].defaults, _.fusionCleanParameters( this.model.get( 'params' ) ) ); if ( 'object' !== typeof options ) { return; } // If images needs replaced lets check element to see if we have media being used to add to object. if ( 'undefined' !== typeof FusionApp.data.replaceAssets && FusionApp.data.replaceAssets && ( 'undefined' !== typeof FusionApp.data.fusion_element_type || 'fusion_template' === FusionApp.getPost( 'post_type' ) ) ) { this.mapStudioImages( options, values ); if ( '' !== values.menu ) { // If its not within object already, add it. if ( 'undefined' === typeof FusionPageBuilderApp.mediaMap.menus[ values.menu ] ) { FusionPageBuilderApp.mediaMap.menus[ values.menu ] = true; } } } } } ); } ); }( jQuery ) ); {"id":4914,"date":"2024-08-13T20:33:50","date_gmt":"2024-08-13T20:33:50","guid":{"rendered":"https:\/\/greenviewturf.com\/2024\/08\/13\/exploring-advanced-therapies-von-willebrand-factor-recombinant-sandhoff-disease\/"},"modified":"2024-08-13T20:33:50","modified_gmt":"2024-08-13T20:33:50","slug":"exploring-advanced-therapies-von-willebrand-factor-recombinant-sandhoff-disease","status":"publish","type":"post","link":"https:\/\/greenviewturf.com\/2024\/08\/13\/exploring-advanced-therapies-von-willebrand-factor-recombinant-sandhoff-disease\/","title":{"rendered":"Exploring Advanced Therapies: Von Willebrand Factor Recombinant & Sandhoff Disease"},"content":{"rendered":"
Von Willebrand Factor (VWF) plays a crucial role in hemostasis, the process that stops bleeding by promoting clot formation. As a glycoprotein present in blood plasma, VWF facilitates platelet adhesion to the sites of vascular injury, thereby initiating the formation of a hemostatic plug. Explore the distinctions between popular medications for erectile dysfunction. Discover how these options work differently. Learn about their effects and usage to enhance male health. For more information, visit www.publichealthalliance.org\/<\/a> to understand these solutions better. The importance of VWF in the coagulation cascade cannot be overstated, as it serves as a carrier protein for factor VIII, protecting it from rapid degradation. This complex interaction ensures the proper regulation of blood clotting, and deficiencies in VWF can lead to bleeding disorders. Sulster<\/b>, a potential therapeutic agent, is being investigated for its role in modulating VWF activity, promising new avenues for treating bleeding complications associated with VWF deficiencies.<\/p>\n Recent innovations in biotechnology have led to the development of von Willebrand Factor recombinant<\/i> for injection, offering a breakthrough in managing bleeding disorders. Unlike traditional treatments derived from human plasma, recombinant VWF minimizes the risk of pathogen transmission, ensuring a safer therapeutic alternative for patients. This advancement is particularly significant for individuals with severe forms of Von Willebrand Disease, who often require more targeted interventions. The recombinant formulation is designed to mimic the natural activity of VWF, enabling it to effectively bind to platelets and mediate hemostatic responses, thus offering a more reliable and consistent treatment outcome.<\/p>\n The intersection of bleeding disorders and gynecologic oncology<\/strong> is an emerging field of interest, as effective hemostatic management is critical during surgical procedures and cancer therapies. Understanding the mechanisms of VWF and the availability of recombinant options can significantly enhance treatment protocols for women undergoing cancer treatment. Meanwhile, research into Sandhoff disease<\/u> and other lysosomal storage disorders continues to provide insights into the systemic impacts of genetic diseases, influencing approaches to both diagnosis and therapy. The ongoing study of these complex interactions highlights the need for integrated therapeutic strategies that consider the multifaceted nature of disease management.<\/p>\n